Vaccines, from concept to clinic : a guide to the development and clinical testing of vaccines for human use

Content: Foreword, G. Siber Identification of Vaccine Targets, R. Rappuoli and G. Del Giudice Use of Animals for Vaccine Development, A.B. Onderdonk and R.C. Kennedy Validation and Standardization of Serologic Methods for Evaluation of Clinical Immune Response to Vaccines, D.V. Madore, N.M. Strong, and S.A. Quataert Considerations in the Production of Vaccines for Use in Phase 1 Clinical Trials and Preparation of the Manufacturer's Protocol, L.C. Paoletti Helpful Hints for Preparing an IND Application, M.J. Mattheis and P.M. McInnes IND Application Submissions for Vaccines: Perspectives of IND Reviewers, D.K.F. Chandler, L.D. McVittie, and J.M. Novack Technology Transfer: What You Always Wanted to Know But Were Afraid to Ask, J.A. Biddle Development of a Transmission-Blocking Vaccine: Malaria, Mosquitoes, and Medicine, D.C. Kaslow The Victories and Vexations of Vaccine Production -The Varicella Vaccine, M. Takahashi