Carbohydrate-Based Vaccines and Immunotherapies

The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments.

With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances.

Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include:

• Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi

• Using adjuvants to improve immunogenicity and/or immunological properties of vaccines

• Choosing and designing proper adjuvants for specific targets

• Abnormal carbohydrates expressed by tumors

• Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy

• Clinical trials results for synthetic cancer vaccines

• Glycoengineering of cell surface carborhydrates and its anticancer applications

• Using cell surface carbohydrates for disease diagnosis

A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.Content:
Chapter 1 Glycobiology and Immunology (pages 1–53): Udayanath Aich and Kevin J. Yarema
Chapter 2 Preparation of Glycoconjugate Vaccines (pages 55–88): Wei Zou and Harold J. Jennings
Chapter 3 Adjuvants for Protein? and Carbohydrate?Based Vaccines (pages 89–115