NK Cells in Cancer Immunotherapy: Successes and Challenges
Anahid Jewett & Yuman Fong
Natural killer (NK) cells are the key immune effectors with the ability to lyse stem-like/poorly differentiated tumor cells and mediate differentiation through their cytotoxic activity and via secretion of IFN-γ and TNF-α, respectively. In this book chapter, we describe the basic biology of NKcells and their function in cancer as well as the impact of the tumor microenvironment on NK cell function.
Furthermore, we present a novel strategy for the expansion of allogenic NK cells, which results in the production of large numbers of highly functional supercharged NK cells. Moreover, we discuss the recent advances in the application of NK cells in cancer immunotherapy.
The combination of standard anticancer treatments with recently established immunotherapeutic approaches with NK cells should provide the optimal conditions for the eradication of tumors.
Furthermore, we present a novel strategy for the expansion of allogenic NK cells, which results in the production of large numbers of highly functional supercharged NK cells. Moreover, we discuss the recent advances in the application of NK cells in cancer immunotherapy.
The combination of standard anticancer treatments with recently established immunotherapeutic approaches with NK cells should provide the optimal conditions for the eradication of tumors.
卷:
4
年:
2023
出版社:
Academic Press
语言:
english
页:
496
ISBN 10:
012822620X
ISBN 13:
9780128226209
系列:
Breaking Tolerance to Anti-Cancer Cell-Mediated Immunotherapy Series
文件:
PDF, 15.85 MB
IPFS:
,
english, 2023
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